منابع مشابه
Chromatin: Sub Out the Replacement
Nucleosomes with specific histone variants are incorporated into DNA at sites of transcription and repair. The histone variant H3.3 has been linked to transcriptional regulation, but genetic tests in the fruit fly have yielded surprising results.
متن کاملHistone modification and replacement in chromatin activation.
Histones are subject to a complex and dynamic set of covalent modifications that are thought to be involved in the modulation of transcription during development, in X chromosome inactivation in female mammals, and in genome stability and meiotic chromosome dynamics. Histone modifications reported to date include acetylation, phosphorylation, methylation, ADP ribosylation, and ubiquitination (F...
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Human remodeling and spacing factor (RSF) consists of a heterodimer of Rsf-1 and hSNF2H, a counterpart of Drosophila ISWI. RSF possesses not only chromatin remodeling activity but also chromatin assembly activity in vitro. While no other single factor can execute the same activities as RSF, the biological significance of RSF remained unknown. To investigate the in vivo function of RSF, we gener...
متن کاملTHE EFFECT OF MECHLOROETHAMIN ON RECONSTITUTED CHROMATIN
In this study the effect of a methylated derivative of nitrogen mustard (mechloroethamin) on solubilized and reconstituted chromatin was investigated using UVNis spectroscopy, DNA and SDS gel electrophoresis and densitomeoic scanning techniques, The results indicated that the 210 and 260 nm absorbances of reconstituted chromatin were decreased in a dose-dependent manner after treatment wit...
متن کاملthe impact of sub-valvular apparatus preservation on prosthetic valve dysfunction during mitral valve replacement
conclusions preservation of mitral annulus and papillary muscle continuity may enhance post- mvr cardiac performance with low mortality and morbidity rates. the risk of pvd was not significantly higher than conventional mvr in our series. results the improvement of functional status was seen in almost all survivors but was more obvious in the group i. in early follow-up, 56.4% of group i cases ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2009
ISSN: 0960-9822
DOI: 10.1016/j.cub.2009.06.032